Current Area of Interest

The Glycoscience Research Cluster (GRC) brings together Ireland’s growing body of expertise in this subject; it focuses on deciphering and exploiting the role of host mucosal glycans on the microbial ecology of the gut.

My role in this program is to analyze alterations in epithelial cell and mucin glycosylation in the colonisation/infection model of a mucosal surface. Therefore, it will be of fundamental relevance to understanding glycan-driven mechanisms in mucosal defence. Methods for isolation and analysis of mucin glycosylation using HPLC and MS will be improved and applied to the samples generated. Furthermore, this glycosylation analysis will not only provide structural data on relevant oligosaccharides, but will also indicate relative activities of glycosyltransferases and other glycosylation determining enzymes.

Contact Information

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Cluster Details

Further information regarding the AGRC project can be found here.